Visualization of the relationship between macrophage and wound healing from the perspective of bibliometric analysis

Author:

Guo Qiang12,Li Wanqing3,Xie Ruijie45ORCID,Wang Yulin1,Xie Yuchen6,Cheng Kunming7,Sun Zhiming18

Affiliation:

1. Department of Clinical College of Neurology, Neurosurgery and Neurorehabilitation Tianjin Medical University Tianjin China

2. Department of Orthopaedic Surgery Tianjin Baodi Hospital Tianjin China

3. Department of Operating Room Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science Xiangyang China

4. Department of Microsurgery The Affiliated Nanhua Hospital, Hengyang Medical school, University of South China Hengyang China

5. Division of Clinical Epidemiology and Aging Research German Cancer Research Center (DKFZ) Heidelberg Germany

6. Department of Clinical Medicine Xiangya Medical College, Central South University Changsha Hunan China

7. Department of Intensive Care Unit The Second Affiliated Hospital of Zhengzhou University Zhengzhou Henan China

8. Department of The Third Central Clinical College Tianjin Medical University Tianjin China

Abstract

AbstractMacrophages play a crucial role in aiding all phases of the wound‐healing process and has garnered increasing attention recently. Although a substantial body of related studies has been published, there remains a lack of comprehensive bibliometric analysis. In this study, we collected 4296 papers from the Web of Science Core Collection database. Three tools including CiteSpace, VOSviewer and one online analytical platform were employed to conduct bibliometric analysis and data visualization. Our results revealed that the annual number of publications related to macrophage and wound healing has increased exponentially with the year. The United States and China stand as the primary driving forces within this field, collectively constituting 58.2% of the total publication output. The application of biomaterials was one of the most concerned research areas in this field. According to references analysis, the current research focus has shifted to diabetic wound healing and regulating macrophage polarization. Based on the keywords analysis, we identified the following research frontiers in the future: exosomes and other extracellular vesicles; bio‐derived materials and drug delivery methods such as nanoparticles, scaffolds and hydrogels; immunomodulation and macrophage polarization in the M2‐state; chronic wounds, particularly those associated with diabetes; antimicrobial peptides; and antioxidant. Additionally, TNF, IL‐6, IL‐10, TGF‐β1 and VEGF ranked as the five genes that have garnered the most research attention in the intersection of macrophage and wound healing. All in all, our findings offered researchers a holistic view of the ongoing progress in the field of macrophages and wound healing, serving as a valuable reference for scholars and policymakers in this domain.

Publisher

Wiley

Subject

Dermatology,Surgery

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