Addressing exaggeration of effects from single RCTs

Author:

van Zwet Erik1ORCID,Schwab Simon2ORCID,Greenland Sander3ORCID

Affiliation:

1. Associate professor of medical statistics at the Leiden University Medical Center.

2. Postdoctoral researcher at the Center for Reproducible Science and the Department of Biostatistics at the University of Zurich.

3. Emeritus professor of epidemiology and statistics at University of California, Los Angeles.

Publisher

Wiley

Subject

Statistics and Probability

Reference7 articles.

1. Schwab S.(2020)Re-estimating 400 000 treatment effects from intervention studies in the Cochrane Database of Systematic Reviews [Data set]. Open Science Framework.doi.org/10.17605/OSF.IO/XJV9G.

2. Publication bias in meta-analyses from the Cochrane Database of Systematic Reviews;Kicinski M.;Statistics in Medicine,2015

3. vanZwet E. W. Schwab S.andSenn S. J.(2021) The statistical properties of RCTs and a proposal for shrinkage.Statistics in Medicine.doi.org/10.1002/sim.9173

4. The importance of beta, the Type II error and sample size in the design and interpretation of the randomized control trial: Survey of 71 “negative” trials;Freiman J. A.;New England Journal of Medicine,1978

5. Why most discovered true associations are inflated;Ioannidis J. P.;Epidemiology,2008

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