Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury

Author:

Cross M J1,Berridge B R2,Clements P J M3,Cove-Smith L4,Force T L5,Hoffmann P6,Holbrook M7,Lyon A R8,Mellor H R9,Norris A A1,Pirmohamed M10,Tugwood J D4,Sidaway J E11,Park B K1

Affiliation:

1. MRC Centre for Drug Safety Science; Department of Molecular and Clinical Pharmacology; University of Liverpool; Liverpool UK

2. Safety Assessment; GlaxoSmithKline; Research Triangle Park NC USA

3. David Jack Centre for Research & Development; GlaxoSmithKline; Ware Herts UK

4. Clinical & Experimental Pharmacology; Cancer Research UK Manchester Institute; University of Manchester; Manchester UK

5. Center for Translational Medicine and Cardiology Division; Temple University School of Medicine; Philadelphia PA USA

6. Preclinical Safety; Novartis Pharm Corp; East Hanover NJ USA

7. Safety Pharmacology; Covance Laboratories, Ltd.; Harrogate North Yorkshire UK

8. NIHR Cardiovascular Biomedical Research Unit; Royal Brompton Hospital and Imperial College; London UK

9. Drug Safety Evaluation; Vertex Pharmaceuticals (Europe), Ltd.; Abingdon Oxfordshire UK

10. The Wolfson Centre for Personalised Medicine; Institute of Translational Medicine; University of Liverpool; Liverpool UK

11. Innovative Medicines; AstraZeneca R&D; Macclesfield UK

Funder

Medical Research Council

Publisher

Wiley

Subject

Pharmacology

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