Effect of <scp>RNS60</scp> in amyotrophic lateral sclerosis: a phase <scp>II</scp> multicentre, randomized, double‐blind, placebo‐controlled trial-Reference-Cited by-同舟云学术

Effect of RNS60 in amyotrophic lateral sclerosis: a phase II multicentre, randomized, double‐blind, placebo‐controlled trial

Published:2022-10-07 Issue:1 Volume:30 Page:69-86
ISSN:1351-5101
Container-title:European Journal of Neurology
language:en
Short-container-title:Euro J of Neurology

Author:

Beghi Ettore¹^ORCID,Pupillo Elisabetta¹^ORCID,Bianchi Elisa¹,Bonetto Valentina¹^ORCID,Luotti Silvia¹,Pasetto Laura¹,Bendotti Caterina¹,Tortarolo Massimo¹,Sironi Francesca¹,Camporeale Laura¹,Sherman Alexander V.²,Paganoni Sabrina³⁴,Scognamiglio Ada⁵,De Marchi Fabiola⁵^ORCID,Bongioanni Paolo⁶,Del Carratore Renata⁷^ORCID,Caponnetto Claudia⁸,Diamanti Luca⁹^ORCID,Martinelli Daniele⁹,Calvo Andrea¹⁰^ORCID,Filosto Massimiliano¹¹^ORCID,Padovani Alessandro¹¹,Piccinelli Stefano Cotti¹¹,Ricci Claudia¹²,Dalla Giacoma Stefania¹²,De Angelis Nicoletta¹²,Inghilleri Maurizio¹³,Spataro Rossella¹⁴^ORCID,La Bella Vincenzo¹⁴^ORCID,Logroscino Giancarlo¹⁵¹⁶,Lunetta Christian¹⁷,Tarlarini Claudia¹⁷,Mandrioli Jessica¹⁸¹⁹,Martinelli Ilaria¹⁹²⁰^ORCID,Simonini Cecilia¹⁹,Zucchi Elisabetta¹⁹²¹,Monsurrò Maria Rosaria²²,Ricciardi Dario²²^ORCID,Trojsi Francesca²²,Riva Nilo²³^ORCID,Filippi Massimo²³^ORCID,Simone Isabella Laura²⁴^ORCID,Sorarù Gianni²⁵^ORCID,Spera Cristina²⁶,Florio Lucia²⁷,Messina Sonia²⁸,Russo Massimo²⁸,Siciliano Gabriele²⁹,Conte Amelia³⁰,Saddi Maria Valeria³¹,Carboni Nicola³¹,Mazzini Letizia⁵,Enia Gabriele,Zucchella Andrea,Pinzani Lorenzo,De Giorgi Lorena,Nicoletti Celeste,Semprucci Elisa,Davide Arippol Emilio,Giussani Giorgia,Graziani Monica,Ferrari Cinzia,Cantello Roberto,Bersano Enrica,Dolciotti Cristina,Masciandaro Silvia Maria,Da Prato Ilaria,Cabona Corrado,Meo Giuseppe,Ceroni Mauro,Dal Fabbro Beatrice,Chiò Adriano,Moglia Cristina,Manera Umberto,Fuda Giuseppe,Casale Federico,De Marco Giovanni,Salamone Paolina,Giannini Fabio,Bocci Silvia,Ceccanti Marco,Cambieri Chiara,Libonati Laura,Moret Federica,Frasca Vittorio,Coletti Tiziana,Tortelli Rosanna,Capozzo Rosa,Gerardi Francesca,Sansone Valeria,Fini Nicola,Gianferrari Giulia,Gessani Annalisa,Falzone Yuri,Schito Paride,Pozzi Laura,Domi Teuta,D’Errico Eustachio,Morea Antonella,Milella Gianmarco,Gizzi Matteo,Paci Francesca,Ferracchiato Simonetta,Zarrelli Michele,Desina Nino,Govoni Alessandra,Schirinzi Erika,Simoncini Costanza,Sabatelli Mario,Bernardo Daniela,Bisogni Giulia,Piras Giovanna,Monne Maria,Manca Elisabetta,

Affiliation:

1. Istituto di Ricerche Farmacologiche Mario Negri IRCCS Milano Italy

2. Neurological Clinical Research Institute Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA

3. Sean M. Healey and AMG Center for ALS at Mass General Hospital Department of Neurology Boston Massachusetts USA

4. Spaulding Rehabilitation Hospital Department of PM&R Harvard Medical School Boston Massachusetts USA

5. ALS Expert Center ‘Maggiore della Carità’ Hospital and University of Piemonte Orientale Novara Italy

6. Spinal Cord Injuries Section Azienda Ospedaliero‐Universitaria Pisana Pisa Italy

7. Institute of Clinical Physiology, CNR‐ Pisa Italy

8. IRCCS Ospedale Policlinico San Martino Genoa Italy

9. IRCCS Mondino Foundation Pavia Italy

10. Centro Regionale Esperto per la Sclerosi Laterale Amiotrofica Dipartimento di Neuroscienze ‘Rita Levi Montalcini’ Università degli Studi di Torino AOU Città della Salute e della Scienza di Torino Torino Italy

11. Department of Clinical and Experimental Sciences University of Brescia Gussago Brescia Italy

12. Department of Medical, Surgical and Neurological Sciences University of Siena Siena Italy

13. Università di Roma ‘Sapienza’ UOSD Malattie Neurodegenerative Centro Malattie Rare Neuromuscolari Policlinico Universitario Umberto I Roma Italy

14. ALS Clinical Research Center AOUP ‘P Giaccone’ ‐ University of Palermo Palermo Italy

15. Center for neurodegenerative diseases and the Aging Brain Department of Clinical Research in Neurology of the University of Bari at ‘Pia Fondazione Card G. Panico ‘Hospital Tricase Tricase Italy

16. Department of Basic Medicine Neuroscience and Sense Organs University Aldo Moro Bari Bari Italy

17. Centro Clinico NeMO Milano Fondazione Serena ONLUS Milan Italy

18. Department of Biomedical Metabolic and Neural Sciences University of Modena and Reggio Emilia Modena Italy

19. Department of Neurosciences Azienda Ospedaliero‐Universitaria Di Modena Modena Italy

20. Clinical and Experimental Medicine PhD Program University of Modena and Reggio Emilia Modena Italy

21. Neuroscience PhD Program University of Modena and Reggio Emilia Modena Italy

22. Department of Advanced Medical and Surgical Sciences University of Campania ‘Luigi Vanvitelli’ Naples Italy

23. Neurology Unit Neurorehabilitation Unit, and Neurophysiology Unit Vita‐Salute San Raffaele University and San Raffaele Scientific Institute Milan Italy

24. Neurology Unit Department of Basic Medical Sciences Neurosciences and Sense Organs University of Bari Bari Italy

25. Motor Neuton Disease Center Department of Neurosciences Azienda Ospedale Università di Padova Padova Italy

26. Azienda Ospedaliera ‘S Maria’ Terni Terni Italy

27. Neurology Department Fondazione IRCCS Casa Sollievo della Sofferenza San Giovanni Rotondo Italy

28. Department of Clinical and Experimental Medicine University of Messina Messina Italy

29. Department of clinical and experimental medicine University of Pisa Pisa Italy

30. Centro Clinico NEMO‐Fondazione Policlinico Universitario A. Gemelli IRCCS Roma Italy

31. Neurology Department San Francesco Hospital Nuoro Italy

Funder

Massachusetts General Hospital

Publisher

Wiley

Subject

Neurology (clinical),Neurology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/ene.15573

Reference40 articles.

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3. Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial

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5. Mitochondrial Dysfunction, Neurogenesis, and Epigenetics: Putative Implications for Amyotrophic Lateral Sclerosis Neurodegeneration and Treatment

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