Regulated vascular smooth muscle cell death in vascular diseases

Author:

Yin Zheng123,Zhang Jishou123,Shen Zican123,Qin Juan‐Juan14,Wan Jun123ORCID,Wang Menglong123

Affiliation:

1. Department of Cardiology, Renmin Hospital of Wuhan University, Department of Geriatrics Zhongnan Hospital of Wuhan University, Wuhan University Wuhan China

2. Cardiovascular Research Institute, Wuhan University Wuhan China

3. Hubei Key Laboratory of Cardiology Wuhan China

4. Center for Healthy Aging, Wuhan University School of Nursing Wuhan China

Abstract

AbstractRegulated cell death (RCD) is a complex process that involves several cell types and plays a crucial role in vascular diseases. Vascular smooth muscle cells (VSMCs) are the predominant elements of the medial layer of blood vessels, and their regulated death contributes to the pathogenesis of vascular diseases. The types of regulated VSMC death include apoptosis, necroptosis, pyroptosis, ferroptosis, parthanatos, and autophagy‐dependent cell death (ADCD). In this review, we summarize the current evidence of regulated VSMC death pathways in major vascular diseases, such as atherosclerosis, vascular calcification, aortic aneurysm and dissection, hypertension, pulmonary arterial hypertension, neointimal hyperplasia, and inherited vascular diseases. All forms of RCD constitute a single, coordinated cell death system in which one pathway can compensate for another during disease progression. Pharmacologically targeting RCD pathways has potential for slowing and reversing disease progression, but challenges remain. A better understanding of the role of regulated VSMC death in vascular diseases and the underlying mechanisms may lead to novel pharmacological developments and help clinicians address the residual cardiovascular risk in patients with cardiovascular diseases.

Funder

National Natural Science Foundation of China

Publisher

Wiley

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