Effect of P-glycoprotein inhibition at the blood-brain barrier on brain distribution of (R)-[11C]verapamil in elderlyvs.young subjects-Reference-Cited by-同舟云学术

Effect of P-glycoprotein inhibition at the blood-brain barrier on brain distribution of (R)-[11C]verapamil in elderlyvs.young subjects

Published:2017-05-04 Issue:9 Volume:83 Page:1991-1999
ISSN:0306-5251
Container-title:British Journal of Clinical Pharmacology
language:en
Short-container-title:Br J Clin Pharmacol

Author:

Bauer Martin¹,Wulkersdorfer Beatrix¹,Karch Rudolf²,Philippe Cécile³,Jäger Walter⁴,Stanek Johann¹⁵,Wadsak Wolfgang³⁶,Hacker Marcus³,Zeitlinger Markus¹,Langer Oliver¹³⁵

Affiliation:

1. Department of Clinical Pharmacology; Medical University of Vienna; Vienna Austria

2. Centre for Medical Statistics, Informatics, and Intelligent Systems; Medical University of Vienna; Vienna Austria

3. Department of Biomedical Imaging und Image-guided Therapy, Division of Nuclear Medicine; Medical University of Vienna; Vienna Austria

4. Department of Clinical Pharmacy and Diagnostics; University of Vienna; Vienna Austria

5. Health and Environment Department; AIT Austrian Institute of Technology GmbH; Seibersdorf Austria

6. Centre for Biomarker Research in Medicine - CBmed GmbH; Graz Austria

Funder

Austrian Science Fund

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/bcp.13301/fullpdf

Reference44 articles.

1. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands;Southan;Nucleic Acids Res,2016

2. The Concise Guide to PHARMACOLOGY 2015/16: Transporters;Alexander;Br J Pharmacol,2015

3. Structure and function of the blood-brain barrier;Abbott;Neurobiol Dis,2010

4. Drug interactions at the blood-brain barrier: fact or fantasy?;Eyal;Pharmacol Ther,2009

5. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs;Schinkel;Cell,1994

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