Assessment of maternal serum SERPINC1, E‐selectin, P‐selectin, and RBP4 levels in pregnancies with early‐ and late‐onset preeclampsia

Abstract

AbstractIntroductionTo investigate whether the SERPINC1, E‐selectin, P‐selectin, and RBP4 levels in first trimester maternal serum was associated with the presence of preeclampsia (PE).MethodsThis cross‐sectional study was conducted on 26 women with early‐onset preeclampsia (EO‐PE), 27 women with late‐onset preeclampsia (LO‐PE), and 27 women with uncomplicated pregnancies. Levels of serum SERPINC1, E‐selectin, P‐selectin, and RBP4 were measured with the use of an enzyme‐linked immunosorbent assay (ELISA) kit.ResultsE‐Selectin levels in patients with EO‐PE were higher than those with LO‐PE and control patients (pE‐L = 0.025; pE‐C = 0.000; p < 0.05). There was no significant intergroup difference in terms of P‐selectin and RBP4 levels (p > 0.05). SERPINC1 levels were lower in the patients in the with EO‐PE group than in those in the LO‐PE and the control groups (pE‐L = 0.000; pE‐C = 0.000; p < 0.05). In the PE group, there was a negative, moderate (41.7%) correlation between E‐selectin level and SERPINC1 (p = 0.002; p < 0.05). The receiver operating characteristic (ROC) curve showed that the best cut‐off values for E‐selectin were 23.14 ng/ml > with 100% sensitivity and 100% specificity. The ROC curve showed that the best cut‐off values for SERPINC1 were ≤87.76 ng/ml with 98.1% sensitivity and 96.3% specificity.DiscussionOf the endothelial damage parameters, E‐selectin and SERPINC1 are especially associated with EO‐PE. Furthermore, they can be used as potential early diagnosis markers in the prediction of PE.