Repeated immunosuppressive rabbit antithymocyte globulin therapy for adult patients with relapsed or refractory aplastic anemia-Reference-Cited by-同舟云学术

Repeated immunosuppressive rabbit antithymocyte globulin therapy for adult patients with relapsed or refractory aplastic anemia

Published:2023-08-07 Issue:5 Volume:111 Page:768-776
ISSN:0902-4441
Container-title:European Journal of Haematology
language:en
Short-container-title:European J of Haematology

Author:

Sakamoto Tatsuhiro¹^ORCID,Obara Naoshi¹^ORCID,Maruyama Yumiko²^ORCID,Kato Takayasu¹^ORCID,Kurita Naoki¹^ORCID,Hattori Keiichiro¹^ORCID,Suehara Yasuhito³^ORCID,Nishikii Hidekazu¹²^ORCID,Yokoyama Yasuhisa¹^ORCID,Sakata‐Yanagimoto Mamiko¹⁴^ORCID,Usuki Kensuke⁵^ORCID,Chiba Shigeru¹^ORCID

Affiliation:

1. Department of Hematology, Faculty of Medicine University of Tsukuba Tsukuba Japan

2. Department of Transfusion Medicine University of Tsukuba Hospital Tsukuba Japan

3. Department of Hematology University of Tsukuba Hospital Tsukuba Japan

4. Division of Advanced Hemato‐Oncology Transborder Medical Research Center Tsukuba Japan

5. NTT Medical Center Tokyo Shinagawa Japan

Abstract

AbstractObjectivesImmunosuppressive therapy (IST) with antithymocyte globulin (ATG) and cyclosporin A is the standard treatment for aplastic anemia (AA). However, the efficacy of repeated IST with rabbit ATG (rATG) as salvage therapy remains unclear in patients with relapsed or refractory AA.MethodsWe retrospectively evaluated the efficacy and safety of IST2 with rATG (IST2‐rATG) in 19 consecutive patients with relapsed or refractory AA who received first‐line IST with rATG in two centers between 2009 and 2020.ResultsThe overall 6‐month response rate of the patients was 58%. The response rates were similar between patients with relapsed and refractory AA. The presence of glycophosphatidylinositol‐deficient blood cells was associated with a better response to IST2‐rATG. Despite retreatment with the same rATG, serum disease and severe allergic reactions were not observed.ConclusionIST2‐rATG is effective and safe for the treatment of adult patients with relapsed and refractory AA after receiving first‐line IST with rATG.

Funder

Japan Society for the Promotion of Science

Publisher

Wiley

Subject

Hematology,General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/ejh.14075

Reference23 articles.

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