Association of dietary calcium with mortality from all causes, cardiovascular disease and cancer in people with hypertension
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Published:2023-04-13
Issue:5
Volume:25
Page:480-488
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ISSN:1524-6175
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Container-title:The Journal of Clinical Hypertension
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language:en
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Short-container-title:J of Clinical Hypertension
Author:
Lin Ruilang1,
Feng Wen2,
Yang Yating1,
Xu Jiaqin1,
Yang Hui1,
Wu Jingyi1,
Li Jiong3,
Qin Guoyou14,
Yu Yongfu14,
Chen Jiaohua5ORCID
Affiliation:
1. Department of Biostatistics School of Public Health The Key Laboratory of Public Health Safety of Ministry of Education Fudan University Shanghai China
2. Department of Pre‐treatment Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine Shanghai China
3. Department of Clinical Medicine—Department of Clinical Epidemiology Aarhus University Aarhus Denmark
4. Shanghai Institute of Infectious Disease and Biosecurity Shanghai China
5. Department of Health Management Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine Shanghai China
Abstract
AbstractAssociation between calcium intake and premature mortality in the general population has been well studied, but little is known about the association among specific populations. The authors aim to evaluate the association among people with hypertension and to provide a proper reference range of dietary calcium intake. This prospective cohort study included 8534 US adults with hypertension from National Health and Nutrition Examination Survey cycles 2003–2014. Dietary calcium intakes were self‐reported and mortality status was ascertained by National Death Index records. During a median follow‐up of 5.9 years, 1357 death occurred. Compared with participants of dietary calcium intake in quintile 1, participants in quintiles 2 and 4 had a 27% (HR: 0.73, 95% CI: 0.60–0.89) and a 29% lower risk (HR: 0.71, 95% CI: 0.57–0.88) of all‐cause mortality respectively. The authors also observed a 34% lower risk (HR: 0.66, 95% CI: 0.45–0.97) of CVD death among participants in quintile 3 and a 37% lower risk (HR: 0.63, 95% CI: 0.40–0.99) of cancer‐related death in participants in quintile 4 respectively. Restricted cubic spline (RCS) regression revealed a consistent protective effect of dietary calcium in participants with a daily intake of over 1000 mg, but a daily intake over 1200 mg fails to show further protective effect. Our findings suggest that elevated dietary calcium was associated with lower mortality risk from all‐causes, cardiovascular disease (CVD) and cancer, and supplying sufficient dietary calcium intake, between 1000 and 1200 mg per day, in people with hypertension may be considered cost‐effective to decrease risk of premature death.
Funder
National Natural Science Foundation of China
Shanghai Rising-Star Program
Natural Science Foundation of Shanghai
Science and Technology Commission of Shanghai Municipality
Subject
Cardiology and Cardiovascular Medicine,Endocrinology, Diabetes and Metabolism,Internal Medicine
Cited by
1 articles.
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