Pimavanserin, a 5HT 2A receptor inverse agonist, rapidly suppresses Aβ production and related pathology in a mouse model of Alzheimer’s disease-Reference-Cited by-同舟云学术

Pimavanserin, a 5HT 2A receptor inverse agonist, rapidly suppresses Aβ production and related pathology in a mouse model of Alzheimer’s disease

Published:2021-01-10 Issue:5 Volume:156 Page:658-673
ISSN:0022-3042
Container-title:Journal of Neurochemistry
language:en
Short-container-title:J. Neurochem.

Author:

Yuede Carla M.¹²³,Wallace Clare E.¹²³,Davis Todd A.¹²³,Gardiner Woodrow D.¹²³,Hettinger Jane C.¹²³,Edwards Hannah M.¹²³,Hendrix Rachel D.¹²³^ORCID,Doherty Brookelyn M.¹²³,Yuede Kayla M.¹²³,Burstein Ethan S.⁴,Cirrito John R.¹²³^ORCID

Affiliation:

1. Department of Neurology Washington University School of Medicine St. Louis MO USA

2. Knight Alzheimer’s Disease Research CenterWashington University School of Medicine St. Louis MO USA

3. Hope Center for Neurological Disorders Washington University School of Medicine St. Louis MO USA

4. ACADIA Pharmaceuticals Inc San Diego CA USA

Funder

ACADIA Pharmaceuticals

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/jnc.15260

Reference56 articles.

1. Pimavanserin tartrate, a 5-HT2A receptor inverse agonist, increases slow wave sleep as measured by polysomnography in healthy adult volunteers

2. Pimavanserin in Alzheimer's disease psychosis: Efficacy in patients with more pronounced psychotic symptoms;Ballard C.;The Journal of Prevention of Alzheimer's Disease,2019

3. Neuronal activity regulates the regional vulnerability to amyloid-β deposition

4. Opioid System and Alzheimer’s Disease

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Unraveling the Potential Underlying Mechanisms of Mild Behavioral Impairment: Focusing on Amyloid and Tau Pathology;Cells;2024-07-08

2. Patterns of Expression of the Key Genes of the BDNF System and Serotonin Receptors in the Brain of OXYS Rats in the Development of the Signs of Alzheimer’s Disease;Advances in Gerontology;2023-06

3. A Cre-deleter specific for embryo-derived brain macrophages reveals distinct features of microglia and border macrophages;Immunity;2023-05

4. Molecular mechanisms of Alzheimer's disease: From therapeutic targets to promising drugs;Fundamental & Clinical Pharmacology;2023-01-13

5. The Missing Piece? A Case for Microglia’s Prominent Role in the Therapeutic Action of Anesthetics, Ketamine, and Psychedelics;Neurochemical Research;2022-11-03