Pharmacokinetic modelling and validation of the half-life extension needed to reduce the burden of infusions compared with standard factor VIII

Author:

Hermans C.1ORCID,Mahlangu J.2ORCID,Booth J.3ORCID,Schütz H.4ORCID,Santagostino E.5,Young G.6ORCID,Lee H.-Y.7,Steinitz-Trost K. N.8,Blanchette V.9,Berntorp E.10

Affiliation:

1. Haemostasis and Thrombosis Unit; Division of Haematology; Cliniques Universitaires Saint-Luc; Brussels Belgium

2. Faculty of Health Sciences; Charlotte Maxeke Johannesburg Academic Hospital; University of the Witwatersrand and National Health Laboratory Service; Johannesburg South Africa

3. Shire; Cambridge MA USA

4. BEBAC; Vienna Austria

5. A. Bianchi Bonomi Hemophilia and Thrombosis Center; IRCCS Ca’ Granda Foundation; Maggiore Hospital Policlinico of Milan; Milan Italy

6. Children's Hospital Los Angeles; University of Southern California Keck School of Medicine; Los Angeles CA USA

7. Shire; Zurich Switzerland

8. Shire; Vienna Austria

9. Department of Pediatrics; Division of Hematology/Oncology; The Hospital for Sick Children; University of Toronto; Toronto Canada

10. Centre for Thrombosis and Haemostasis; Lund University; Malmö Sweden

Publisher

Wiley

Subject

Genetics(clinical),Hematology,General Medicine

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