Mathematical modeling and simulation in animal health. Part III: Using nonlinear mixed-effects to characterize and quantify variability in drug pharmacokinetics

Author:

Bon C.1,Toutain P. L.2ORCID,Concordet D.345,Gehring R.6ORCID,Martin-Jimenez T.7,Smith J.8,Pelligand L.2,Martinez M.9ORCID,Whittem T.10,Riviere J. E.6,Mochel J. P.11ORCID

Affiliation:

1. Roche Pharmaceutical Research and Early Development; Roche Innovation Center; Basel Switzerland

2. Department of Veterinary Basic Sciences; Royal Veterinary College; Hatfield UK

3. Toxalim, Research Centre in Food Toxicology; Toulouse France

4. Université de Toulouse; ENVT, INP, Toxalim; Toulouse France

5. Laboratoire de Physiologie et Thérapeutique; École Nationale Vétérinaire de Toulouse INRA; UMR 1331; Toulouse France

6. Department of Anatomy and Physiology; College of Veterinary Medicine; Institute of Computational Comparative Medicine (ICCM); Kansas State University; Manhattan KS USA

7. Department of Comparative Medicine; College of Veterinary Medicine; University of Tennessee; Knoxville TN USA

8. Veterinary Diagnostic and Production Animal Medicine; Iowa State University College of Veterinary Medicine; Ames IA USA

9. Center for Veterinary Medicine; US Food and Drug Administration; Rockville MD USA

10. Translational Research and Animal Clinical Trials (TRACTs) Group; Faculty of Veterinary and Agricultural Sciences; University of Melbourne; Werribee Vic. Australia

11. Biomedical Sciences; Iowa State University College of Veterinary Medicine; Ames IA USA

Publisher

Wiley

Subject

General Veterinary,Pharmacology

Reference81 articles.

1. Likelihood based approaches to handling data below the quantification limit using NONMEM VI;Ahn;Journal of Pharmacokinetics and Pharmacodynamics,2008

2. Experimental design and efficient parameter estimation in population pharmacokinetics;Al-Banna;Journal of Pharmacokinetics and Biopharmaceutics,1990

3. Ways to fit a PK model with some data below the quantification limit;Beal;Journal of Pharmacokinetics and Pharmacodynamics,2001

4. Handling data below the limit of quantification in mixed effect models;Bergstrand;American Association of Pharmaceutical Scientists Journal,2009

5. Pharmacokinetic-Pharmacodynamic Modeling and Simulation

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