Development of a double‐layer electrospun patch as a potential prenatal treatment for myelomeningocele

Author:

Benabdderrahmane K.1,Stirnemann J.23,Ramtani S.1,Falentin‐Daudré C.1

Affiliation:

1. LBPS/CSPBAT, UMR CNRS 7244, Institut Galilée Université Sorbonne Paris Nord Villetaneuse France

2. Obstetrics and Maternal‐Fetal Medicine, Hôpital Necker Enfants Malades, AP‐HP Paris France

3. EA7328 Institut Imagine & Université de Paris‐Cité Paris France

Abstract

AbstractMyelomeningocele (MMC) is a congenital defect of the spine characterised by meningeal and spinal cord protrusion through the open vertebral arches. This defect causes progressive prenatal damage of the spinal cord, leading to lifelong handicap. Although mid‐trimester surgical repair may reduce part of the handicap, an earlier and less invasive approach would further improve the prognosis, possibly minimising maternal and foetal risks. Several studies have proposed an alternative approach to surgical repair by covering the defect with a patch and protecting the exposed neural tissue. Our study aims to elaborate on a waterproof and biodegradable bioactive patch for MMC prenatal foetal repair. We developed a double‐layer patch that can provide a waterproof coverage for the spinal cord, with a bioactive side, conducive to cell proliferation, and an antiadhesive side to avoid its attachment to the medulla.

Publisher

Wiley

Subject

Dermatology,Surgery

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