Does Wilson's disease determine specific personality traits? Analysis of patients with the neurological form of the disease

Author:

Seniów Joanna1ORCID,Roessler‐Górecka Magdalena1,Cudo Andrzej2,Członkowska Anna1

Affiliation:

1. 2nd Department of Neurology Institute of Psychiatry and Neurology Warsaw Poland

2. Department of Experimental Psychology The John Paul II Catholic University of Lublin Lublin Poland

Abstract

AbstractBackgroundIn the autosomal recessive disorder of copper metabolism, Wilson's disease (WD), patients present hepatic, neurological, and psychiatric symptoms combined in different and unpredictable ways. Brain pathology primarily affects the basal ganglia and may cause movement, cognitive, affective, and behavioral disturbances. Personality traits have been rarely studied in the neurological form of the disease.ObjectiveTo investigate whether patients with the neurological form of WD (WDn) have specific personality traits, especially those typical of frontobasal loop dysfunction.MethodsThe personality of 29 adult WDn patients (without significant cognitive and psychiatric disorders) and 29 matched healthy controls was assessed using the Minnesota Multiphasic Personality Inventory (MMPI‐2).ResultsCompared to healthy individuals, patients with WDn scored higher on the following MMPI‐2 scales: hypochondriasis, physical malfunctioning, bizarre sensory experiences, health concerns, and general health concerns, with no differentiation between patients and controls on the remaining MMPI‐2 scales.ConclusionsLong‐term treated patients with WDn did not appear to have any specific personality traits reflecting unambiguously frontobasal psychopathology, if self‐report measurement is used. The more strongly exhibited features concerning their actual physical ailments and health anxiety, such as hypochondria, chronic fatigue, and poor psychophysical well‐being, could result from psychological reactions to a chronic disabling brain disease. Further study of personality traits and personality disorders is warranted in patients with clearly defined forms of WD, using various measurement tools. Psychopathological disorders in different forms of WD warrant further studies.

Publisher

Wiley

Reference23 articles.

1. Diagnosis and treatment of Wilson's disease an update;Roberts E;Hepatology,2008

2. A multidisciplinary approach to the diagnosis and management of Wilson disease: 2022 practice guidance on Wilson disease from the American Association for the Study of Liver Diseases;Schilsky ML;Hepatology,2023

3. Corticobasal syndrome: a practical guide;Wilson D;Pract Neurol,2021

4. Clinical assessment of prefrontal lobe functions;Henri‐Bhargava A;Behavioral Neurology and Psychiatry,2018

5. Wilson disease: brain pathology;Poujois A;Handb Clin Neurol,2017

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3