Low seroprotection against diphtheria and tetanus in Lao adolescents-Reference-Cited by-同舟云学术

Low seroprotection against diphtheria and tetanus in Lao adolescents

Published:2023-05-18 Issue:6 Volume:28 Page:501-506
ISSN:1360-2276
Container-title:Tropical Medicine & International Health
language:en
Short-container-title:Tropical Med Int Health

Author:

Vantava Sonephet¹,Hefele Lisa²,Virachith Siriphone³,Vannachone Souphaphone¹,Khounvisith Vilaysone³,Nouanthong Phonethipsavanh³,Hübschen Judith M.²,Sayasone Somphou¹,Black Antony P.³

Affiliation:

1. Lao Tropical and Public Health Institute, Ministry of Health Vientiane Lao People's Democratic Republic

2. Department of Infection and Immunity Luxembourg Institute of Health Esch‐sur‐Alzette Grand‐Duchy of Luxembourg

3. Lao‐Lux Laboratory Institut Pasteur du Laos Vientiane Lao People's Democratic Republic

Abstract

AbstractObjectivesThere is currently no booster diphtheria or tetanus vaccine for Lao children before adolescence, despite international recommendations. We investigated seroprotection against diphtheria and tetanus among Lao adolescents.MethodsSeven hundred seventy‐nine serum samples were tested for anti‐diphtheria and anti‐tetanus antibodies.ResultsOverall, 25.8% of the adolescents had antibody titers corresponding to protection against diphtheria and 30.9% to sufficient immunity against tetanus. Female participants >16 years were more likely to be protected against diphtheria (p < 0.001) and tetanus (p < 0.029).ConclusionLow protection against diphtheria and tetanus, possibly due to low vaccination coverage or antibody waning, suggests booster doses are warranted before adolescence.

Publisher

Wiley

Subject

Infectious Diseases,Public Health, Environmental and Occupational Health,Parasitology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/tmi.13882

Reference23 articles.

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3. World Health Organization.Tetanus [Internet]. [cited 2020 Jun 18]. Available from:https://www.who.int/health-topics/tetanus/#tab=tab_1

4. Tetanus vaccines: WHO position paper – February 2017;WHO;Wkly Epidemiol Rep,2017

5. Lao Statistics Bureau.Statistical Yearbook 2018 [Internet]. Yearbook 2018. Vientiane Lao PDR.2019. Available from:https://www.lsb.gov.la/en/

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