Affiliation:
1. State Key Laboratory of Robotics, Shenyang Institute of Automation Chinese Academy of Sciences Shenyang China
2. Institutes for Robotics and Intelligent Manufacturing Chinese Academy of Sciences Shenyang China
3. University of Chinese Academy of Sciences Beijing China
Abstract
AbstractThe advent of atomic force microscopy (AFM) provides an amazing instrument for characterising the structures and properties of living biological systems under aqueous conditions with unprecedented spatiotemporal resolution. In addition to its own unique capabilities for applications in life sciences, AFM is highly compatible and has been widely integrated with various complementary techniques to simultaneously sense the multidimensional (biological, chemical and physical) properties of biological systems, offering novel possibilities for comprehensively revealing the underlying mechanisms guiding life activities particularly in the studies of single cells. Herein, typical combinations of AFM and complementary techniques (including optical microscopy, ultrasound, infrared spectroscopy, Raman spectroscopy, fluidic force microscopy and traction force microscopy) and their applications in single‐cell analysis are reviewed. The future perspectives are also provided.
Funder
National Natural Science Foundation of China
Subject
Histology,Pathology and Forensic Medicine
Cited by
3 articles.
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