Affiliation:
1. Ufa Institute of Chemistry, Ufa Federal Research Centre Russian Academy of Science Ufa Russia
2. Martin‐Luther‐University Halle‐Wittenberg, Organic Chemistry Halle (Saale) Germany
Abstract
AbstractA series of new betulin, lupeol, erythrodiol, and oleanolic acid phosphoryloxy‐ and furoyloxy‐derivatives has been synthesized and their structure was confirmed by NMR spectroscopy. Synthesized compounds were subjected to Ellman's assays to determine their ability to inhibit the enzymes AChE and BChE. Among them, diethoxyphosphoryloxy‐oleanolic acid inhibited BChE with a value of 99%, thereby acting as a mixed‐type inhibitor holding very low Ki values of Ki = 6.59 nM and Ki’ = 1.97 nM, respectively.
Funder
Russian Science Foundation