Tolerance to nitroglycerin through proteasomal down‐regulation of aldehyde dehydrogenase‐2 in a genetic mouse model of ascorbate deficiency
Author:
Affiliation:
1. Department of Pharmacology and Toxicology Karl‐Franzens‐Universität Graz Graz Austria
2. Department of Pathology and Laboratory Medicine University of North Carolina Chapel Hill NC USA
Publisher
Wiley
Subject
Pharmacology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1111/bph.12081
Reference40 articles.
1. Proteasome inhibitor up regulates liver antioxidative enzymes in rat model of alcoholic liver disease
2. Dietary supplement with vitamin C prevents nitrate tolerance.
3. Vascular Bioactivation of Nitroglycerin Is Catalyzed by Cytosolic Aldehyde Dehydrogenase-2
4. Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the Heart
5. Identification of the enzymatic mechanism of nitroglycerin bioactivation
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