Increased proportion of CD226 + CD14 + monocytes correlates with clinical features and laboratory parameters in patients with primary Sjögren's syndrome

Author:

Zhao Ping12,Cheng Wei13,Liu Cuiping4,Peng Cheng1,Shen Yu4,Yang Yanhong5,Sun Chao2,Chang Xin1,Wu Jian1ORCID

Affiliation:

1. Department of Rheumatology The First Affiliated Hospital of Soochow University Suzhou China

2. Department of Rheumatology The First Affiliated Hospital of Bengbu Medical College Bengbu China

3. Department of Dermatology Changsu NO2 People's Hospital Changshu, Suzhou China

4. Jiangsu Key Laboratory of Clinical Immunology The First Affiliated Hospital of Soochow University Suzhou China

5. Department of Obstetrics and Gynecology Second Affiliated Hospital of Soochow University Suzhou China

Abstract

AbstractObjectivesCD226 is widely expressed on the surface of immune cells as a co‐stimulatory receptor, which is involved in the development of many autoimmune diseases. The purpose of this study was to investigate the proportion of CD226 on CD14 + monocytes in the peripheral circulation of patients with primary Sjögren's syndrome (pSS) and the clinical significance of pSS.MethodsThe proportion of CD226 on the surface of CD14 + monocytes was measured by flow cytometry in 45 pSS patients and 25 healthy controls (HC). The correlations between the proportion of CD226 + CD14 + monocytes and the clinical features and laboratory parameters of pSS were analyzed. Meanwhile, we analyzed the change in proportion of CD226 + CD14 + monocytes before and after treatment, and the clinical significance of pSS was evaluated.ResultsThe proportion of CD226 on CD14 + monocytes markedly increased in pSS patients compared to HC (p < .01). We found the proportion of CD226 + CD14 + monocytes was positively correlated with the disease activity and severity of pSS patients. The proportion of CD226 + CD14 + monocytes in pSS patients with decayed tooth, fatigue, interstitial lung disease (ILD), low WBC, high IgG, anti‐Ro60, and anti‐SSB positive increased compared to that in negative patients (p < .05). Furthermore, the proportion of CD226 + CD14 + monocytes was significantly higher in active patients than in nonactive patients (p < .01). Additionally, the proportion of CD226 + CD14 + monocytes decreased in seven pSS patients after treatment (p < .01).ConclusionOur study suggested that an increased CD226 proportion on CD14 + monocytes was associated with the clinical manifestations, disease activity, and prognosis of pSS patients. CD226+ CD14 + monocytes may present a potential target and a biomarker for the prognosis and therapy of pSS patients.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Rheumatology

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