Understanding the pathogenic mechanisms and therapeutic effects in neurocysticercosis

Author:

Castillo Gino1ORCID,Fustamante Lizbeth1,Delgado‐Kamiche Ana D.12,Camen‐Orozco Rogger P.12,Clark Taryn34,Bernal Edson1,Morales‐Alvarez Jemima1,Ferrufino Maria5,Mamani‐Palomino Javier6,Bustos Javier A.7,Garcia Hector H.8,Gavidia Cesar M.9,Gilman Robert H.3ORCID,Verastegui Manuela110ORCID,

Affiliation:

1. Infectious Diseases Laboratory Research‐LID, Facultad de Ciencia e Ingeniería Universidad Peruana Cayetano Heredia Lima Peru

2. Solomon H. Snyder Department of Neuroscience Johns Hopkins University School of Medicine Baltimore United States

3. The Department of International Health, Bloomberg School of Hygiene and Public Health Johns Hopkins University Baltimore Maryland USA

4. Department of Emergency Medicine, SUNY Downstate Medical Center Kings County Hospital Medical Center, Brooklyn, New York New York United States

5. Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston Texas USA

6. Facultad de Medicina Veterinaria y Salud animal Universidad Peruana Cayetano Heredia Lima Peru

7. Center for Global Health Universidad Peruana Cayetano Heredia Lima Peru

8. Cysticercosis Unit Instituto Nacional de Ciencias Neurológicas Lima Peru

9. School of Veterinary Medicine Universidad Nacional Mayor de San Marcos Lima Peru

10. Asociación Benéfica Prisma Lima Peru

Abstract

AbstractDespite being a leading cause of acquired seizures in endemic regions, the pathological mechanisms of neurocysticercosis are still poorly understood. This study aims to investigate the impact of anthelmintic treatment on neuropathological features in a rat model of neurocysticercosis. Rats were intracranially infected with Taenia solium oncospheres and treated with albendazole + praziquantel (ABZ), oxfendazole + praziquantel (OXF), or untreated placebo (UT) for 7 days. Following the last dose of treatment, brain tissues were evaluated at 24 h and 2 months. We performed neuropathological assessment for cyst damage, perilesional brain inflammation, presence of axonal spheroids, and spongy changes. Both treatments showed comparable efficacy in cyst damage and inflammation. The presence of spongy change correlated with spheroids counts and were not affected by anthelmintic treatment. Compared to white matter, gray matter showed greater spongy change (91.7% vs. 21.4%, p < 0.0001), higher spheroids count (45.2 vs. 0.2, p = 0.0001), and increased inflammation (72.0% vs. 21.4%, p = 0.003). In this rat model, anthelmintic treatment destroyed brain parasitic cysts at the cost of local inflammation similar to what is described in human neurocysticercosis. Axonal spheroids and spongy changes as markers of damage were topographically correlated, and not affected by anthelmintic treatment.

Funder

Fondo Nacional de Desarrollo Científico, Tecnológico y de Innovación Tecnológica

National Institutes of Health

Publisher

Wiley

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Neurocysticercosis and the Central Nervous System: Advancements in Diagnosis, Treatment, and Future Prospects;Intestinal Parasites - New Developments in Diagnosis, Treatment, Prevention and Future Directions [Working Title];2024-06-10

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