A simultaneous oral and intramuscular prime/sublingual boost with a DNA/Modified Vaccinia Ankara viral vector-based vaccine induces simian immunodeficiency virus-specific systemic and mucosal immune responses in juvenile rhesus macaques

Author:

Curtis Alan D.1,Jensen Kara1,Van Rompay Koen K. A.2,Amara Rama R.3,Kozlowski Pamela A.4,De Paris Kristina1ORCID

Affiliation:

1. Department of Microbiology and Immunology; University of North Carolina at Chapel Hill; Chapel Hill North Carolina

2. California National Primate Research Center; University of California; Davis California

3. Yerkes National Primate Research Center; Emory University; Atlanta Georgia

4. Department of Microbiology, Immunology and Parasitology; Louisiana State University Health Sciences Center; New Orleans Louisiana

Funder

National Institutes of Health

Office of Research Infrastructure Programs/OD

Center for AIDS Research, University of Washington

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill

North Carolina Biotech Center Institutional Support

Publisher

Wiley

Subject

General Veterinary,Animal Science and Zoology

Reference45 articles.

1. Time to prioritise the UNAIDS 90-90-90 targets for infants;Ananworanich;Lancet HIV,2016

2. Earlier initiation of ART and further decline in mother-to-child HIV transmission rates, 2000-2011;Townsend;AIDS,2014

3. Immunogenicity of viral vector, prime-boost SIV vaccine regimens in infant rhesus macaques: attenuated vesicular stomatitis virus (VSV) and modified vaccinia Ankara (MVA) recombinant SIV vaccines compared to live-attenuated SIV;Van Rompay;Vaccine,2010

4. Challenges in the elimination of pediatric HIV-1 infection;Luzuriaga;N Engl J Med,2016

5. Balancing trained immunity with persistent immune activation and the risk of SIV infection in infant macaques vaccinated with attenuated Mycobacterium tuberculosis or BCG vaccines;Jensen;Clin Vaccine Immunol,2016

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