HPV vaccine stimulates cytotoxic activity of killer dendritic cells and natural killer cells against HPV ‐positive tumour cells

Author:

Van den Bergh Johan M. J.1,Guerti Khadija2,Willemen Yannick1,Lion Eva1,Cools Nathalie1,Goossens Herman3,Vorsters Alex4,Van Tendeloo Viggo F. I.1,Anguille Sébastien1,Van Damme Pierre4,Smits Evelien L. J. M.15

Affiliation:

1. Laboratory of Experimental Hematology Vaccine and Infectious Disease Institute (VAXINFECTIO) Faculty of Medicine & Health Sciences University of Antwerp Antwerp Belgium

2. Division of Immunology Department of Laboratory Medicine Antwerp University Hospital Edegem Belgium

3. Laboratory of Medical Microbiology Vaccine and Infectious Disease Institute (VAXINFECTIO) Faculty of Medicine & Health Sciences University of Antwerp Antwerp Belgium

4. Centre for the Evaluation of Vaccination (CEV) Vaccine and Infectious Disease Institute (VAXINFECTIO) Faculty of Medicine & Health Sciences University of Antwerp Antwerp Belgium

5. Center for Oncological Research Antwerp Faculty of Medicine & Health Sciences University of Antwerp Antwerp Belgium

Publisher

Wiley

Subject

Cell Biology,Molecular Medicine

Reference40 articles.

1. EMA. Available athttp://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000721/human_med_000694.jsp***[and]***mid=WC0b01ac058001d124 London UK 2007.

2. FDA. Available athttp://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm186959.htm Rockville MD 2009.

3. AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity

4. Molecular and structural characterization of the L1 virus-like particles that are used as vaccine antigens inCervarix™, the AS04-adjuvanted HPV-16 and -18 cervical cancer vaccine

5. Development of an AS04-Adjuvanted HPV Vaccine with the Adjuvant System Approach

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