Gastroschisis and septo‐optic‐pituitary dysplasia: Is there an association?

Author:

Salman Michael S1ORCID,Ruth Chelsea A2,Yogendran Marina S3,Zrinyi Anna4,Morris Melanie4

Affiliation:

1. Section of Pediatric Neurology University of Manitoba Winnipeg Manitoba Canada

2. Section of Neonatology, Department of Pediatrics and Child Health University of Manitoba Winnipeg Manitoba Canada

3. Department of Community Health Sciences University of Manitoba Winnipeg Manitoba Canada

4. Section of Pediatric Surgery, Department of Surgery, Max Rady College of Medicine, Rady Faculty of Health Sciences University of Manitoba Winnipeg Manitoba Canada

Abstract

AimThere are several case reports describing patients with both optic nerve hypoplasia/septo‐optic‐pituitary dysplasia (ONH/SOD) and gastroschisis (GS). Our aim was to investigate whether ONH/SOD is associated with GS.MethodsA retrospective population‐based study was undertaken using the Population Research Data Repository at the Manitoba Center for Health Policy in Manitoba, Canada to investigate if any patient with ONH/SOD also had GS. In addition, Winnipeg's Surgical Database of Outcomes and Management (WiSDOM), a hospital‐based paediatric surgical database, was searched to ascertain if any of the patients with GS also have ONH/SOD.ResultsCases were 124 patients with ONH/SOD diagnosed during 1990–2019. None had GS. The surgical database had 188 patients from Manitoba with GS during 1991–2019. None had ONH/SOD.ConclusionThere does not appear to be an association between ONH/SOD and GS in our cohorts of patients with these two disorders.

Funder

Foundation Fighting Blindness

Children's Hospital Research Institute of Manitoba

Publisher

Wiley

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