A rare BRAF T599dup mutation conferring sensitivity to BRAF inhibitor in a patient with metastatic melanoma

Author:

Marchand A.1,Tallet A.2,Collin C.2,Cormier B.3,Venel Y.4,Miquelestorena-Standley E.35,Machet L.15ORCID

Affiliation:

1. Department of Dermatology; CHRU Tours; Tours France

2. Platform of Somatic Tumor Molecular Genetics; CHRU Tours; Tours France

3. Pathology; CHRU Tours; Tours France

4. Nuclear Medicine; CHRU Tours; Tours France

5. Université de Tours; Tours France

Publisher

Wiley

Subject

Dermatology

Reference5 articles.

1. Combined vemurafenib and cobimetinib in BRAF-mutated melanoma;Larkin;N Engl J Med,2014

2. Improved overall survival in melanoma with combined dabrafenib and trametinib;Robert;N Engl J Med,2015

3. Diagnosis and treatment of melanoma. European consensus-based interdisciplinary guideline - update 2016;Garbe;Eur J Cancer,2016

4. COSMIC Mutation COSM30730 http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=30730

5. Novel BRAF mutation in melanoma: a case report;Trubini;Mol Clin Oncol,2018

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