Autophagy dysfunction and regulatory cystatin C in macrophage death of atherosclerosis

Author:

Li Wei1,Sultana Nargis2,Siraj Nabeel23,Ward Liam J12,Pawlik Monika4,Levy Efrat5,Jovinge Stefan6,Bengtsson Eva6,Yuan Xi-Ming2

Affiliation:

1. Division of Obstetrics and Gynaecology; Department of Clinical and Experimental Medicine; Faculty of Health Sciences; Linköping University; Linköping Sweden

2. Occupational and Environmental Medicine Center; Heart and Medicine Center; County Council of Östergötland; Linköping Sweden

3. Department of internal medicine; University of Alberta Edmonton; Alberta Canada

4. Nathan S. Kline Institute for Psychiatric Research; Orangeburg NY USA

5. Nathan S. Kline Institute for Psychiatric Research; Departments of Psychiatry and Biochemistry and Molecular Pharmacology; New York University Langone School of Medicine; New York NY USA

6. Department of Clinical Sciences; Skåne University Hospital; Lund University; Lund Sweden

Funder

Swedish Heart Lung Foundation

Torsten Söderbergs Stiftelse

Stroke Foundation

Olle Engkvist Foundation

Swedish Gamla Tjänarinnor Foundation

Linköping University and Linköping University Hospital Research Foundation

Magnus Bergvalls Stiftelse

Syskonen Svensson Foundation

Crafoordska Stiftelsen

Kungliga Fysiografiska Sällskapet i Lund

Lars Hierta Foundation

Lundström Foundation

Malmö University Hospital Foundation

Swedish Society of Medicine

USA National Institutes of Health

Publisher

Wiley

Subject

Cell Biology,Molecular Medicine

Reference31 articles.

1. “Vulnerable plaques”-ticking of the time bomb;Mitra;Can J Physiol Pharmacol,2004

2. Uptake of oxidized LDL by macrophages differs from that of acetyl LDL and leads to expansion of an acidic endolysosomal compartment;Lougheed;Arterioscler Thromb Vasc Biol,1999

3. Effects of cellular cholesterol loading on macrophage foam cell lysosome acidification;Cox;J Lipid Res,2007

4. Uptake of oxidized LDL by macrophages results in partial lysosomal enzyme inactivation and relocation;Li;Arterioscler Thromb Vasc Biol,1998

5. Oxidized low density lipoprotein is resistant to cathepsins and accumulates within macrophages;Lougheed;J Biol Chem,1991

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