1. Department of Anesthesiology; First Affiliated Hospital of China Medical University; Shenyang Liaoning 110001 China
2. Institute of Metabolic Disease Research and Drug Development; China Medical University; Shenyang Liaoning 110122 China
3. Department of Pharmacology; School of Pharmacy; China Medical University; Shenyang Liaoning 110122 China
4. Division of Biological Sciences; Department of Medicine; University of Chicago; Chicago IL 60637 USA