Prothrombin complex concentrate vs. fresh frozen plasma in adult patients undergoing heart surgery – a pilot randomised controlled trial (PROPHESY trial)

Author:

Green L.123ORCID,Roberts N.4,Cooper J.5,Agarwal S.6,Brunskill S.J.7,Chang I.5,Gill R.8,Johnston A.9,Klein A. A.10,Platton S.3,Rossi A.4,Sepehripour A.4,Stanworth S.1112,Monk V.5,O'Brien B.1113

Affiliation:

1. Blizard Institute Barts and the London School of Medicine Queen Mary University of London London UK

2. Department of Haematology Barts Health NHS Trust London UK

3. Department of Cardiac Surgery Barts Health NHS Trust London UK

4. William Harvey Research Institute Barts and the London School of Medicine Queen Mary University of London London UK

5. Department of Anaesthesia Manchester Royal Infirmary Manchester UK

6. Systematic Review Initiative NHS Blood and Transplant Oxford UK

7. Department of Anaesthesia University Hospital Southampton Southampton UK

8. William Harvey Research Institute Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK

9. Department of Anaesthesia Royal Papworth Hospital Cambridge UK

10. Department of Haematology Oxford University Hospitals NHS Foundation Trust Oxford UK

11. Department of Anaesthesia Barts Health NHS Trust London UK

12. NHS Blood and Transplant Oxford UK

13. Outcomes Research Consortium, Cleveland Clinic OH USA

Funder

British Heart Foundation

Publisher

Wiley

Subject

Anesthesiology and Pain Medicine

Reference18 articles.

1. Increased Mortality, Postoperative Morbidity, and Cost After Red Blood Cell Transfusion in Patients Having Cardiac Surgery

2. A practical guideline for the haematological management of major haemorrhage

3. Transfusion NCAoB Audit of Blood Transfusion in Adult Cardiac Surgery.2011.https://nhsbtdbe.blob.core.windows.net/umbraco‐assets‐corp/14923/nca‐2011_use_of_blood_in_adult_cardiac_surgery_report.pdf(accessed 30/10/2020).

4. Fresh frozen plasma for cardiovascular surgery;Desborough M;Cochrane Database of Systematic Reviews,2015

5. Prothrombin Complex Concentrate in Cardiac Surgery: A Systematic Review and Meta-Analysis

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