A Study onCYP2C19andCYP2D6Polymorphic Effects on Pharmacokinetics and Pharmacodynamics of Amitriptyline in Healthy Koreans-Reference-Cited by-同舟云学术

A Study onCYP2C19andCYP2D6Polymorphic Effects on Pharmacokinetics and Pharmacodynamics of Amitriptyline in Healthy Koreans

Published:2017-03 Issue:2 Volume:10 Page:93-101
ISSN:1752-8054
Container-title:Clinical and Translational Science
language:en
Short-container-title:Clinical And Translational Science

Author:

Ryu S¹,Park S¹,Lee JH¹,Kim YR¹,Na HS¹,Lim HS²,Choi HY²,Hwang IY¹,Lee JG¹,Park ZW¹,Oh WY¹,Kim JM¹,Choi SE¹

Affiliation:

1. Clinical Research Division; National Institute of Food and Drug Safety; Ministry of Food and Drug Safety; Republic of Korea

2. Department of Clinical Pharmacology and Therapeutics; College of Medicine; University of Ulsan; Asan Medical Center; Republic of Korea

Funder

Ministry of Food and Drug Safety

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/cts.12451/fullpdf

Reference48 articles.

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3. Demethylation and hydroxylation of amitriptyline, nortriptyline, and 10-hydroxyamitriptyline in human liver microsomes;Mellstrom;Drug Metab. Dispos. Biol. Fate Chem,1981

4. The metabolic fate of amitriptyline, nortriptyline and amitriptylinoxide in man;Breyer-Pfaff;Drug Metab. Rev,2004

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