Comparison of nutrient supply from the dam to fetus and placental development in Holstein and Japanese black cows pregnant with similar or different fetus breeds

Abstract

AbstractA lower nutrient supply from Holstein (HOL) dams to beef fetuses than HOL fetuses has been demonstrated, but the underlying factors remain unclear. We investigated maternal, umbilical vein, and calf blood glucose and amino acid concentrations at calving, along with placental development at term, in HOL dams with similar fetuses (HOL‐HOL, n = 12), F1 crosses (HOL × Japanese Black [JB]; HOL‐F1, n = 4), JB fetuses (HOL‐JB, n = 7), and JB dams with similar fetuses (JB‐JB, n = 11). Calf birth weight, total cotyledonary weight, and surface area were greater in HOL‐HOL compared to JB‐JB or HOL‐JB (P < 0.05), whereas those of HOL‐F1 were similar. Blood amino acid concentrations in the umbilical veins and calves were similar among HOL‐HOL, HOL‐F1, and HOL‐JB. Calf blood glucose concentrations were lower in HOL‐F1 than HOL‐HOL (P < 0.05), despite similar maternal blood glucose levels. HOL‐JB exhibited higher maternal, umbilical vein, and calf blood glucose concentrations than JB‐JB (P < 0.05). Therefore, the glucose supply to the fetus may be inhibited in HOL‐F1 due to maternal‐fetal breed differences. Higher maternal blood glucose concentrations in HOL‐JB may result in elevated fetal glucose exposure, potentially affecting postnatal growth and metabolism.