The role of concentration−effect relationships in the assessment of QTcinterval prolongation

Author:

France Nicholas P.1,Della Pasqua Oscar12

Affiliation:

1. Medicines Discovery and Development; GlaxoSmithKline; Uxbridge UK

2. Department of Pharmacology; School of Life and Medical Sciences; UCL; London UK

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference69 articles.

1. Timing of new black box warnings and withdrawals for prescription medications;Lasser;JAMA,2002

2. Guidance for Industry E14 clinical evaluation of QT/QT c interval prolongation and proarrythmic potential for non-antiarrythmic drugs 2005

3. ICH S7B guidance The non-clinical evaluation of the potential for delayed ventricular repolarization (QT interval prolongation) 2005

4. Performance characteristics for some typical QT study designs under the ICH E-14 guidance;Hutmacher;J Clin Pharmacol,2008

5. Does low-dose droperidol administration increase the risk of drug-induced QT prolongation and torsade de pointes in the general surgical population?;Nuttall;Anesthesiology,2007

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