Affiliation:
1. Division of Reproductive Endocrinology and In Vitro Fertilization (IVF) Department of Obstetrics and Gynecology Lady Davis Carmel Medical Center Haifa Israel
2. Ruth and Bruch Rappaport Faculty of Medicine Technion – Israel Institute of Technology Haifa Israel
Abstract
AbstractAimTo examine the implantation potential of fragmented embryos that underwent morphokinetic evaluation in a time‐lapse incubator.MethodsA retrospective study analyzing 4210 Day 5 embryos which were incubated in a time‐lapse incubator, between 2013 and 2019. Embryos with more than 5% fragmentation (379 embryos) were included in the study. Embryos selected using the general model and re‐examined by our in‐house model. Embryo fragmentation percentage was documented from the first cell‐division (start fragmentation) to its maximal percentage (final fragmentation), and the ratio between them (fragmentation worsening). Data were analyzed with relation to embryo development, embryos transfer or freezing, clinical pregnancy, and live birth rates.ResultsEmbryo fragmentation and morphokinetics were found to be independent variables for clinical pregnancy achievements. A higher fragmentation worsening was noted among discarded embryos compared to transferred or frozen embryos (p < 0.0001). Advanced maternal age had a significant negative effect on fragmentation (p < 0.001). Missed abortion rates were similar in fragmented embryos that implanted compared with the overall population. Live birth rates were comparable among embryos which were selected for transfer or freezing by their morphokinetics and had different severity of fragmentation.ConclusionOur study shows that fragmented embryos have a potential to implant and therefore should be selected for transfer. Laboratories which do not use time‐lapse incubators for embryo selection, should consider transferring fragmented embryos, since they have an acceptable chance for live birth. Calculation of fragmentation worsening may enhance our ability to predict embryo development. Further research with analysis of more fragmented embryo maybe beneficial. This study was approved by the local ethics committee No. 0010‐19 CMC on April 18th, 2019.
Subject
Obstetrics and Gynecology
Cited by
1 articles.
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