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The opioid methadone induces a local anaesthetic-like inhibition of the cardiac Na+channel, Nav1.5

  • Published:2013-12-23 Issue:2 Volume:171 Page:427-437
  • ISSN:0007-1188
  • Container-title:British Journal of Pharmacology
  • language:en
  • Short-container-title:Br J Pharmacol

Author:

Schulze V1,Stoetzer C1,O'Reilly A O2,Eberhardt E2,Foadi N1,Ahrens J1,Wegner F3,Lampert A2,de la Roche J1,Leffler A1

Affiliation:

1. Department of Anesthesiology and Intensive Care Medicine; Hannover Medical School; Hannover Germany

2. Institute of Physiology and Pathophysiology; Friedrich-Alexander-Universität Erlangen-Nürnberg; Erlangen Germany

3. Department of Neurology; Hannover Medical School; Hannover Germany

Publisher

Wiley

Subject

Pharmacology

Reference30 articles.

1. Electrostatic contributions of aromatic residues in the local anesthetic receptor of voltage-gated sodium channels;Ahern;Circ Res,2008

2. The Concise Guide to PHARMACOLOGY 2013/14: Overview;Alexander;Br J Pharmacol,2013

3. Methadone-induced mortality in the treatment of chronic pain: role of QT prolongation;Andrews;Cardiol J,2009

4. Models and mechanisms of local anesthetic cardiac toxicity: a review;Butterworth;Reg Anesth Pain Med,2010

5. A community-based evaluation of sudden death associated with therapeutic levels of methadone;Chugh;Am J Med,2008

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