Affiliation:
1. Experimental Hematology Lab IIS‐Fundación Jimenez Díaz, UAM Madrid Spain
2. Centre for Haemato‐Oncology Barts Cancer Institute, Queen Mary University of London London UK
Abstract
In their paper, using zebrafish models, Gioacchino et al. have demonstrated the GATA2 haploinsufficiency, the genetic hallmark of GATA2 deficiency syndrome, promotes erythroid and myeloid cytopenia, and have discovered a self‐regulatory mechanism to compensate GATA2 levels and protein function.Commentary on: Gioacchino et al. GATA2 heterozygosity causes an epigenetic feedback mechanism resulting in myeloid and erythroid dysplasia. Br J Haematol 2024;205:580‐593.