Association between COVID‐19 vaccination and atrial arrhythmias in individuals with cardiac implantable electronic devices

Author:

Deshmukh Abhishek J.1ORCID,Ahmad Rimsha1,Cha Yong‐Mei1ORCID,Mulpuru Siva K.1ORCID,DeSimone Christopher V.1ORCID,Killu Ammar M.1ORCID,Mullane Steven2,Harrell Camden2,Kutyifa Valentina3ORCID,Cheung Jim W.4ORCID,Upadhyay Gaurav A.5,Piccini Jonathan P.6ORCID,Hayes David L.2,Madhavan Malini1ORCID

Affiliation:

1. Department of Cardiovascular Diseases Mayo Clinic Rochester Minnesota USA

2. BIOTRONIK Inc. Lake Oswego Oregon USA

3. Clinical Cardiovascular Research Center University of Rochester Rochester New York USA

4. Division of Cardiology, Department of Medicine Weill Cornell Medicine/New York‐Presbyterian Hospital New York New York USA

5. The University of Chicago Medicine Pritzker School of Medicine Illinois USA

6. Duke Clinical Research Institute Duke University Durham North Carolina USA

Abstract

AbstractIntroductionThe impact of mRNA‐based coronavirus disease‐2019 (COVID‐19) vaccines on atrial arrhythmias (AA) and ventricular arrhythmias incidence is unknown.MethodsBIOTRONIK Home Monitoring data and Medicare Claims data were utilized to identify individuals implanted with a cardiac implantable electronic device (CIED) between 2010 and 2020 who received one or more doses of COVID‐19 vaccine in 2021. The burden of AA (%) in the 3 months postvaccination was compared to those noted in the preceding 3 months using the Wilcoxon signed rank test. Sub‐analyses comparing the effects of the influenza vaccine against the COVID‐19 vaccine were also evaluated for individuals who received the influenza vaccine in 2020. A 1:1 propensity score match comparison between COVID‐19 vaccine and non‐vaccinated patients was also performed.ResultsFirst and second doses of the COVID‐19 vaccine were administered to 7757 and 6579 individuals with a CIED (age 76.2 ± 9.0 years, 49% males), respectively. While a small but statistically significant increase in the burden of AA was noted in the 3 months postvaccination compared to the preceding 3 months after the first dose of the COVID‐19 vaccine (0.43 ± 9.04%, p = .028) a similar rise in AA was found following the influenza vaccine and for matched patients who did not receive the COVID‐19 vaccine. No significant difference in device therapies was seen pre‐ and postvaccination.ConclusionsThough we report a small but significant increase in the number of CIED‐detected AAs following vaccination for COVID‐19 over a 3‐month window, we believe these results correlate more with time and the progressive nature of AF rather than the vaccine itself. While these data should not dissuade from the use of these vaccines, increased vigilance and prompt treatment of AF is required for high‐risk groups, specifically males over 70 years of age, following vaccination.

Publisher

Wiley

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. COVID‐19 vaccination and atrial fibrillation: When pandemics collide;Journal of Cardiovascular Electrophysiology;2024-08-22

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