Prediction of Safety Margin and Optimization of Dosing Protocol for a Novel Antibiotic using Quantitative Systems Pharmacology Modeling
Author:
Affiliation:
1. DILIsym Services; Inc.; a Simulations Plus company; Research Triangle Park; North Carolina USA
2. University of Basel; Basel Switzerland
3. Basilea Pharmaceutica International Ltd.; Basel Switzerland
4. InSphero; Inc.; Basel Switzerland
Funder
Basilea Pharmaceutica, Inc
Publisher
Wiley
Subject
General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/cts.12560/fullpdf
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3. In vitro activity of the siderophore monosulfactam BAL30072 against contemporary Gram-negative pathogens from New York City, including multidrug-resistant isolates;Landman,;Int. J. Antimicrob. Agents,2014
4. Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072;Paech,;Arch. Toxicol
5. In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsymTM: a mechanistic, mathematical model of DILI;Howell,;J. Pharmacokinet. Pharmacodyn,2012
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