Flotillin‐1 is a prognostic biomarker for glioblastoma and promotes cancer development through enhancing invasion and altering tumour microenvironment

Author:

Wang Ran12ORCID,Chen Zhikang12,Zhang Yi3,Xiao Shihan1,Zhang Wuming1,Hu Xianqin1,Xiao Qun4,Liu Qing4ORCID,Wang Xiangyu4ORCID

Affiliation:

1. Department of Colorectal and Anus Surgery, Xiangya Hospital Central South University Changsha Hunan China

2. The Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital Central South University Changsha Hunan China

3. Department of Neurosurgery, Dengzhou People's Hospital Dengzhou Henan China

4. Department of Neurosurgery, Xiangya Hospital Central South University Changsha Hunan China

Abstract

AbstractFlotillin‐1(FLOT1) has long been recognized as a tumour‐promoting gene in several types of cancer. However, the expression and function of FLOT1 in glioblastomas (GBM) has not been elucidated. Here, in this study, we find that the expression level of FLOT1 in GBM tissue was much higher than that in normal brain, and the expression was even higher in the more aggressive subtypes and IDH status of glioma. Kaplan–Meier survival revealed that high FLOT1 expression is closely associated with poor outcome in GBM patients. FLOT1 knockdown markedly reduced the proliferation, migration and invasiveness of GBM cells, while FLOT1 overexpression significantly increases GBM cell proliferation, migration and invasiveness. Mechanistically, FLOT1 expression may play a potential role in the microenvironment of GBM. Therefore, FLOT1 promotes GBM proliferation and invasion in vitro and in vivo and may serve as a biomarker of prognosis and therapeutic potential in the fight against GBM.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Cell Biology,Molecular Medicine

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