Systemic administration of cytotoxic T lymphocyte‐associated antigen 4 (CTLA‐4)‐Ig abrogates alveolar bone resorption in induced periodontitis through inhibition of osteoclast differentiation and activation: An experimental investigation-Reference-Cited by-同舟云学术

Systemic administration of cytotoxic T lymphocyte‐associated antigen 4 (CTLA‐4)‐Ig abrogates alveolar bone resorption in induced periodontitis through inhibition of osteoclast differentiation and activation: An experimental investigation

Published:2021-06-15 Issue:5 Volume:56 Page:972-981
ISSN:0022-3484
Container-title:Journal of Periodontal Research
language:en
Short-container-title:J Periodont Res

Author:

Nakane Saki¹²,Imamura Kentaro¹²,Hisanaga Rio¹²,Ishihara Kazuyuki²³,Saito Atsushi¹²^ORCID

Affiliation:

1. Department of Periodontology Tokyo Dental College Tokyo Japan

2. Oral Health Science Center Tokyo Dental College Tokyo Japan

3. Department of Microbiology Tokyo Dental College Tokyo Japan

Funder

Japan Society for the Promotion of Science

Publisher

Wiley

Subject

Periodontics

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/jre.12909

Reference49 articles.

1. A new member of the immunoglobulin superfamily—CTLA-4

2. Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.

3. CTLA4Ig: Bridging the Basic Immunology with Clinical Application

4. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

5. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

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