Affiliation:
1. The Second School of Clinical Medicine Southern Medical University Guangzhou China
2. Department of Dermatology Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University Guangzhou China
3. Medical School Shenzhen University Shenzhen China
Abstract
AbstractInterleukin‐17 s (IL‐17s) are well‐known proinflammatory cytokines, and their antagonists perform excellently in the treatment of inflammatory skin diseases such as psoriasis. However, their physiological functions have not been given sufficient attention by clinicians. IL‐17s can protect the host from extracellular pathogens, maintain epithelial integrity, regulate cognitive processes and modulate adipocyte activity through distinct mechanisms. Here, we present a systematic review concerning the physiological functions of IL‐17s. Our goal is not to negate the therapeutic effect of IL‐17 antagonists, but to ensure their safe use and reasonably explain the possible adverse events that may occur in their application.
Funder
National Natural Science Foundation of China
Subject
Dermatology,Molecular Biology,Biochemistry