A hypothesis for the existence of two types of tuberculosis, reflecting two distinct types of immune failure to control the pathogen, based upon prevalence of mycobacterium-specific IgG subclasses

Author:

Menon J.12,Hoeppner V. H.3,Judd A.4,Power C. A.15,Bretscher P. A.1ORCID

Affiliation:

1. Department of Microbiology and Immunology; University of Saskatchewan; Saskatoon SK Canada

2. Sanofi Pasteur; Toronto ON Canada

3. Department of Medicine; University of Saskatchewan; Saskatoon SK Canada

4. Department of Family Medicine; University of Saskatchewan; Saskatoon SK Canada

5. Lowy Cancer Research Centre; University of New South Wales; Sydney NSW Australia

Funder

Saskatchewan Lung Association

Natural Sciences and Engineering Research Council of Canada

Canadian Institutes of Health Research

Publisher

Wiley

Subject

Immunology,General Medicine

Reference27 articles.

1. Immune responsiveness and lymphokine production in patients with tuberculosis and healthy controls;Sanchez;Infect Immun,1994

2. Th1/Th2 profiles in tuberculosis, based on the proliferation and cytokine responses of blood lymphocytes to mycobacterial antigens;Surcel;Immunology,1994

3. An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection;Flynn;J Exp Med,1993

4. Disseminated tuberculosis in interferon gamma gene-disrupted mice;Cooper;J Exp Med,1993

5. Genetic dissection of immunity to mycobacteria: the human model;Casanova;Annu Rev Immunol,2002

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