Psychopathological characteristics in ultra‐high risk for psychosis with and without comorbid ADHD

Author:

Ribolsi Michele12,Prosperi Porta Davide3,Sacco Roberto4,Di Lorenzo Giorgio35ORCID,Fiori Nastro Federico35ORCID,Albergo Giuliano1,Di Lazzaro Vincenzo1,Costa Anna4

Affiliation:

1. Unit of Neurology, Neurophysiology, Neurobiology and Psychiatry, Department of Medicine Campus Bio‐Medico University Rome Italy

2. Istituto Clinico Interuniversitario ‐ Consorzio Universitario Humanitas Rome Italy

3. Chair of Psychiatry, Department of Systems Medicine Tor Vergata University of Rome Rome Italy

4. Unit of Child & Adolescent Neuropsychiatry Campus Bio‐Medico University of Rome Rome Italy

5. IRCCS Fondazione Santa Lucia Rome Italy

Abstract

AbstractAimThis study investigates the psychopathological characteristics of a sample of individuals at ultra‐high risk for psychosis with and without comorbid attention‐deficit hyperactivity disorder (ADHD).MethodsTwenty‐eight subjects (aged 13–21 years; 13 females) with attenuated psychosis syndrome (APS) were recruited in a cross‐sectional study and divided into two groups, each with 14 patients, according to the presence or absence of ADHD.ResultsThe APS group showed a significantly higher prevalence of negative symptoms than the APS + ADHD group. Other characteristics investigated (positive symptoms, aberrant salience, psychotic‐like experiences and prodromal symptoms) did not differ between groups.ConclusionsThe different profiles of negative symptoms in the APS with or without ADHD might suggest the presence of a specific subtype among individuals at ultra‐high risk for psychosis. Longitudinal studies with larger samples will provide information about the role of negative symptoms in determining conversion to full psychosis in those people with ‘pure’ APS and those with APS + ADHD.

Publisher

Wiley

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