Affiliation:
1. Department of Dentistry, Stomatology Clinical Federal University of Vales do Jequitinhonha e Mucuri (UFVJM) Diamantina Minas Gerais Brazil
2. Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP) University of São Paulo Ribeirão Preto São Paulo Brazil
3. Department of Pathology and Forensic Medicine, Ribeirão Preto Medical School (FMRP/USP) University of São Paulo Ribeirão Preto São Paulo Brazil
Abstract
AbstractSyphilis can mimic, clinically and microscopically, many other diseases. By microscopy, typically syphilis presents with plasma cell infiltration, admixed with lymphocytes and macrophages, in lichenoid and/or perivascular/perineural distribution pattern. When exuberant, this inflammatory infiltrate can mimic a lymphoproliferative disorder (LPD), notably plasma cell neoplasia or lymphoma. To date, about 12 cases of secondary syphilis, all but one in extraoral location, suggesting initially a LPD, have been published. Here, to our knowledge, we report an unusual case of intraoral primary syphilis initially suggesting LPD, notably lymphoid hyperplasia (pseudolymphoma); however, mucosa‐associated lymphoid tissue (MALT) lymphoma and follicular lymphoma could not be disregarded. Polyclonality of plasma cells on immunohistochemistry, in strict clinical correlation, was essential to arrive at the correct diagnosis.
Funder
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Fundação de Amparo à Pesquisa do Estado de Minas Gerais
Fundação de Amparo à Pesquisa do Estado de São Paulo
Subject
Dermatology,Histology,Pathology and Forensic Medicine