S3 guideline Atopic dermatitis: Part 2 ‐ Systemic treatment

Author:

Werfel Thomas1,Heratizadeh Annice1,Aberer Werner2,Augustin Matthias3,Biedermann Tilo4,Bauer Andrea5,Fölster‐Holst Regina6,Kahle Julia7,Kinberger Maria8,Nemat Katja9,Neustädter Irena10,Peters Eva11,von Kiedrowski Ralph12,Schmid‐Grendelmeier Peter13,Schmitt Jochen14,Schwennesen Thomas15,Simon Dagmar16,Spindler Thomas17,Traidl‐Hoffmann Claudia18,Werner Ricardo Niklas8,Wollenberg Andreas1920,Worm Margitta21,Ott Hagen22

Affiliation:

1. Department of Dermatology Allergology and Venereology, Hannover Medical School Hannover Germany

2. Department of Dermatology and Venereology Medical University of Graz Graz Austria

3. Competence Center for Health Services Research in Dermatology (CVderm) Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg‐Eppendorf Hamburg Germany

4. Department of Dermatology and Allergology University Medical Center Munich, Technical University of Munich Munich Germany

5. Department of Dermatology University Hospital Carl Gustav Carus, Technical University Dresden Dresden Germany

6. Department of Dermatology Venereology and Allergology, University Hospital Schleswig‐Holstein Campus Kiel Germany

7. German Allergy and Asthma Association (DAAB) Mönchengladbach Germany

8. Department of Dermatology Venereology and Allergology, Division of Evidence Based Medicine in Dermatology (dEBM), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany

9. Office for Pediatric Pneumology and Allergology, Pediatric Center Dresden‐Friedrichstadt (Kid) Dresden Germany

10. Hospital Hallerwiese, Cnopfsche Kinderklinik Nuremberg Germany

11. Department of Psychosomatic Medicine and Psychotherapy University Hospital Gießen Gießen Germany

12. Dermatology Office Selters Germany

13. Allergy Unit, Department of Dermatology University Hospital Zurich Zurich Switzerland

14. Center for Evidence‐Based Healthcare (ZEGV), Medical Faculty Gustav Carus, Technical University Dresden Dresden Germany

15. German Eczema Association (DNB) Hamburg Germany

16. Department of Dermatology, Inselspital Bern Bern Switzerland

17. Specialized Clinic for Pediatric Pneumology and Allergology Wangen Germany

18. Institute of Environmental Medicine University Hospital Augsburg Augsburg Germany

19. Department of Dermatology and Allergology University Hospital Augsburg Augsburg Germany

20. Department of Dermatology and Allergy Ludwig Maximilian University Munich Munich Germany

21. Department of Dermatology Venereology and Allergology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany

22. Department of Pediatric Dermatology and Allergology Children's and Adolescents’ Hospital Auf der Bult Hannover Germany

Abstract

SummaryThe present S3 guideline was created based on the European English‐language S3 guideline, with special consideration given to the medical conditions in the German‐speaking region, and with additions from the previous German‐language version, in accordance with the criteria of the AWMF. This second part of the guideline addresses the systemic therapy of atopic dermatitis (AD). It covers topics such as the indication for systemic therapy in children, adolescents, and adult patients with AD. Furthermore, it addresses all medications approved for AD, such as the biologics dupilumab and tralokinumab, the Janus kinase inhibitors abrocitinib, baricitinib, and upadacitinib, as well as conventional immunosuppressive therapies with systemic glucocorticosteroids and ciclosporin. Additionally, it discusses systemic off‐label therapies. The first part of the guideline, published separately, includes the definition and diagnostic aspects of AD, describes topical therapy, non‐drug therapy approaches, and addresses aspects related to special patient groups.

Publisher

Wiley

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