Population pharmacokinetic-pharmacodynamic modelling to describe the effects of paracetamol and N-acetylcysteine on the international normalized ratio

Author:

Owens Katie H1,Medlicott Natalie J1,Zacharias Mathew2,Whyte Ian M3,Buckley Nicholas A4,Reith David M5

Affiliation:

1. School of Pharmacy; University of Otago; Dunedin New Zealand

2. Dunedin Hospital; Dunedin New Zealand

3. Department of Clinical Toxicology; Calvary Mater Newcastle and School of Medicine and Public Health; University of Newcastle; Newcastle NSW Australia

4. Pharmacology; Sydney Medical School; University of Sydney; Sydney NSW Australia

5. Dunedin School of Medicine; University of Otago; Dunedin New Zealand

Publisher

Wiley

Subject

Physiology (medical),Pharmacology,Physiology

Reference24 articles.

1. Simultaneous modelling of the Michaelis-Menten kinetics of paracetamol sulphation and glucuronidation;Reith;Clin. Exp. Pharmacol. Physiol.,2009

2. Guidelines for the management of paracetamol poisoning in Australia and New Zealand - explanation and elaboration. A consensus statement from clinical toxicologists consulting to the Australasian poisons information centres;Daly;Med. J. Australia,2008

3. Initial prothrombin time as a predictor of acetaminophen-induced hepatotoxicity;Steeg;J. Clin. Toxicol.,1995

4. Management of severe cases of paracetamol overdosage;Makin;Br. J. Hosp. Med.,1994

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