Genetic overexpressing of GPx-1 attenuates cocaine-induced renal toxicity via induction of anti-apoptotic factors

Author:

Mai Huynh Nhu1,Jeong Ji Hoon2,Kim Dae-Joong3,Chung Yoon Hee4,Shin Eun-Joo1,Nguyen Lan Thuy Ty1,Nam Yunsung1,Lee Yu Jeung5,Cho Eun-Hee6,Nah Seung-Yeol7,Jang Choon-Gon8,Lei Xin Gen9,Kim Hyoung-Chun1

Affiliation:

1. Neuropsychopharmacology and Toxicology Program; College of Pharmacy; Kangwon National University; Chunchon Korea

2. Department of Pharmacology; College of Medicine; Chung-Ang University; Seoul Korea

3. Department of Anatomy and Cell Biology; Medical School; Kangwon National University; Chunchon Korea

4. Department of Anatomy; College of Medicine; Chung-Ang University; Seoul Korea

5. Clinical Pharmacy; College of Pharmacy; Kangwon National University; Chunchon Korea

6. Department of Internal Medicine; Medical School; Kangwon National University; Chunchon Korea

7. Ginsentology Research Laboratory and Department of Physiology; College of Veterinary Medicine; Konkuk University; Seoul Korea

8. Department of Pharmacology; School of Pharmacy; Sungkyunkwan University; Suwon Korea

9. Department of Animal Science; Cornell University; Ithaca New York USA

Funder

National Research Foundation of Korea

Korea Food and Drug Administration

Publisher

Wiley

Subject

Physiology (medical),Pharmacology,Physiology

Reference48 articles.

1. Histopathology of cocaine hepatotoxicity. Report of four patients;Wanless;Gastroenterology,1990

2. Cocaine-induced renal disease;Gitman;Expert Opin. Drug Safety,2004

3. Acute renal failure due to rhabdomyolysis associated with cocaine toxicity;Lombard;West. J. Med.,1988

4. Acute bilateral renal infarction secondary to cocaine-induced vasospasm;Madhrira;Kidney Int.,2009

5. Cocaine intoxication: hyperpyrexia, rhabdomyolysis and acute renal failure;Merigian;J. Toxicol. Clin. Toxicol.,1987

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