β-asarone and levodopa co-administration increase striatal dopamine level in 6-hydroxydopamine induced rats by modulating P-glycoprotein and tight junction proteins at the blood-brain barrier and promoting levodopa into the brain

Author:

Huang Liping12,Deng Minzhen2,He Yuping2,Lu Shiyao2,Ma Ruanxin2,Fang Yongqi2

Affiliation:

1. Hainan Medical University; Haikou China

2. The First Affiliated Hospital of Guangzhou University of Chinese Medicine; Guangzhou China

Funder

Guangdong Natural Science Foundation of China

Guangzhou University of Chinese Medicine

First Clinical Medical College of Guangzhou University of Chinese Medicine Excellent Doctoral Dissertation Cultivation Project

Scientific Research Cultivating Fund of Hannan Medical University

Hainan Natural Science Foundation of China

Publisher

Wiley

Subject

Physiology (medical),Pharmacology,Physiology

Reference49 articles.

1. Optimizing levodopa therapy for Parkinson's disease with levodopa/carbidopa entacapone: implications from a clinical and patient perspective;Brooks;Neuropsychiatr. Dis. Treat.,2008

2. Novel aspects of striatal plasticity associated with long-term L-dopa administration;Busceti;Arch. Ital. Biol.,2013

3. Antiparkinsonian drugs and their neuroprotective effects;Kitamura;Biol. Pharm. Bull.,2002

4. Intranasally applied L-DOPA alleviates parkinsonian symptoms in rats with unilateral nigro-striatal 6-OHDA lesions;Chao;Brain Res. Bull.,2012

5. Classics in chemical neuroscience: Levodopa;Whitfield;ACS Chem. Neurosci.,2014

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