Iron-chelating agent, deferasirox, inhibits neutrophil activation and extracellular trap formation-Reference-Cited by-同舟云学术

Iron-chelating agent, deferasirox, inhibits neutrophil activation and extracellular trap formation

Published:2016-09-01 Issue:10 Volume:43 Page:915-920
ISSN:0305-1870
Container-title:Clinical and Experimental Pharmacology and Physiology
language:en
Short-container-title:Clin Exp Pharmacol Physiol

Author:

Kono Mari¹,Saigo Katsuyasu²,Yamamoto Shiori¹,Shirai Kohei²,Iwamoto Shuta²,Uematsu Tomoko²,Takahashi Takayuki³,Imoto Shion⁴,Hashimoto Makoto⁵,Minami Yosuke⁵,Wada Atsushi¹,Takenokuchi Mariko²,Kawano Seiji⁵

Affiliation:

1. Scientific Research; Scientific Affairs; Sysmex Corporation; Kobe Japan

2. Faculty of Pharmacological Sciences; Himeji Dokkyo University; Himeji Japan

3. Department of Hematology; Shinko Hospital; Kobe Japan

4. Department of Health Science; Kobe Tokiwa University; Kobe Japan

5. Kobe University Hospital; Kobe Japan

Publisher

Wiley

Subject

Physiology (medical),Pharmacology,Physiology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/1440-1681.12612/fullpdf

Reference25 articles.

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2. The oral iron chelator deferasirox represses signaling through the mTOR in myeloid leukemia cells by enhancing expression of REDD1;Ohyashiki;Cancer Sci,2009

3. The iron chelator, deferasirox, as a novel strategy for cancer treatment: oral activity against human lung tumor xenografts and molecular mechanism of action;Lui;Mol Pharmacol,2013

4. Deferasirox is a powerful NF-kappaB inhibitor in myelodysplastic cells and in leukemia cell lines acting independently from cell iron deprivation by chelation and reactive oxygen species scavenging;Messa;Haematologica,2010

5. The oral iron chelator deferasirox inhibits NF-κB mediated gene expression without impacting on proximal activation: implications for myelodysplasia and aplastic anaemia;Banerjee;Br J Haematol,2015

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