The pharmacokinetics of methocarbamol and guaifenesin after single intravenous and multiple-dose oral administration of methocarbamol in the horse

Author:

Rumpler M. J.1,Colahan P.2,Sams R. A.1

Affiliation:

1. Department of Physiological Sciences; Florida Racing Laboratory; College of Veterinary Medicine; University of Florida; Gainesville FL USA

2. Department of Large Animal Clinical Sciences; College of Veterinary Medicine; University of Florida; Gainesville FL USA

Funder

Racing Medication and Testing Consortium, Inc

Florida Division of Pari-Mutuel Wagering

Publisher

Wiley

Subject

General Veterinary,Pharmacology

Reference35 articles.

1. Likelihood based approaches to handling data below the quantification limit using NONMEM VI;Ahn;Journal of Pharmacokinetics and Pharmacodynamics,2008

2. Key aspects of analytical method validation and linearity evaluation;Araujo;Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences,2009

3. Ways to fit a PK model with some data below the quantification limit;Beal;Journal of Pharmacokinetics and Pharmacodynamics,2001

4. Metabolism of methocarbamol in the rat, dog, and human;Bruce;Journal of Pharmaceutical Sciences,1971

5. Effects of first-pass metabolism on metabolite mean residence time determination after oral administration of parent drug;Chan;Pharmaceutical Research,1990

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