Generation and basic characterization of a gene‐trap knockout mouse model of Scn2a with a substantial reduction of voltage‐gated sodium channel Na v 1.2 expression-Reference-Cited by-同舟云学术

Generation and basic characterization of a gene‐trap knockout mouse model of Scn2a with a substantial reduction of voltage‐gated sodium channel Na v 1.2 expression

Published:2021-01-18 Issue:4 Volume:20 Page:
ISSN:1601-1848
Container-title:Genes, Brain and Behavior
language:en
Short-container-title:Genes, Brain and Behavior

Author:

Eaton Muriel¹²^ORCID,Zhang Jingliang¹²,Ma Zhixiong¹²,Park Anthony C.¹²,Lietzke Emma¹²,Romero Chloé M.¹²,Liu Yushuang¹²,Coleman Emily R.¹²,Chen Xiaoling¹²,Xiao Tiange¹²,Que Zhefu¹²,Lai Shirong¹²,Wu Jiaxiang¹²,Lee Ji Hea¹²,Palant Sophia¹²,Nguyen Huynhvi P.¹²,Huang Zhuo³,Skarnes William C.⁴,Koss Wendy A.²⁵,Yang Yang¹²

Affiliation:

1. Department of Medicinal Chemistry and Molecular Pharmacology College of Pharmacy, Purdue University West Lafayette Indiana USA

2. Purdue Institute for Integrative Neuroscience Purdue University West Lafayette Indiana USA

3. Department of Molecular and Cellular Pharmacology School of Pharmaceutical Sciences, Peking University Health Science Center Beijing China

4. Department of Cellular Engineering The Jackson Laboratory for Genomic Medicine Farmington Connecticut USA

5. Office of the Executive Vice President for Research and Partnerships Purdue University West Lafayette Indiana USA

Funder

Indiana Clinical and Translational Sciences Institute

Publisher

Wiley

Subject

Behavioral Neuroscience,Neurology,Genetics

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/gbb.12725

Reference78 articles.

1. Elevated expression of type II Na+ channels in hypomyelinated axons of shiverer mouse brain

2. Distribution and function of voltage-gated sodium channels in the nervous system

3. Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones

4. Distinct contributions of Nav1.6 and Nav1.2 in action potential initiation and backpropagation

5. The Autism-Associated Gene Scn2a Contributes to Dendritic Excitability and Synaptic Function in the Prefrontal Cortex

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