Exploring the complexities of drug formulation selection, storage, and shelf‐life for exploration spaceflight-Reference-Cited by-同舟云学术

Exploring the complexities of drug formulation selection, storage, and shelf‐life for exploration spaceflight

Published:2024-01-14 Issue: Volume: Page:
ISSN:0306-5251
Container-title:British Journal of Clinical Pharmacology
language:en
Short-container-title:Brit J Clinical Pharma

Author:

Daniels Vernie R.¹^ORCID,Williams Edward S.²

Affiliation:

1. KBR Houston TX 77058 USA

2. NASA Johnson Space Center Houston TX 77058 USA

Abstract

Medications have been a part of space travel dating back to the Apollo missions. Currently, medical kits aboard the International Space Station (ISS) contain medications and supplies to treat a variety of possible medical events. As we prepare for more distant exploration missions to Mars and beyond, risk management planning for astronaut healthcare should include the assembly of a medication formulary that is comprehensive enough to prevent or treat anticipated medical events, remains safe and chemically stable, and retains sufficient potency to last for the duration of the mission. Emerging innovation and technologies in pharmaceutical development, delivery, quality maintenance, and validation offer promise for addressing these challenges. The present editorial will summarize the current state of knowledge regarding innovative formulary optimization strategies, pharmaceutical stability assessment techniques, and storage and packaging solutions that could enhance drug safety and efficacy for future exploration spaceflight missions.

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/bcp.15957

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