Affiliation:
1. Department of Medicine, Division of Dermatology, Faculty of Medicine Chulalongkorn University Bangkok Thailand
2. Department of Microbiology, Faculty of Science Chulalongkorn University Bangkok Thailand
3. Department of Microbiology, Faculty of Medicine Chulalongkorn University Bangkok Thailand
4. Antimicrobial Resistance and Stewardship Research Unit, Faculty of Medicine Chulalongkorn University Bangkok Thailand
Abstract
AbstractThe effects of topical non‐antibiotic acne treatment on skin microbiota have rarely been demonstrated. In the study, we randomized 45 mild acne vulgaris participants into three treatment groups, including a cream‐gel dermocosmetic containing Aqua Posae Filiformis, lipohydroxy acid, salicylic acid, linoleic acid, niacinamide and piroctone olamine (DC), retinoic acid 0.025% cream (VAA) and benzoyl peroxide 2.5% gel (BP). At months 0, 1 and 3, skin specimens were swabbed from the cheek and forehead and sequenced by targeting V3‐V4 regions of the 16 S rRNA gene. QIIME2 was used to characterize bacterial communities. Acne severity, sebum level and tolerability were assessed concomitantly in each visit. We found that both VAA and BP could significantly reduce the bacterial diversity at month 1 (p‐value = 0.010 and 0.004 respectively), while no significant reduction was observed in DC group. The microbiota compositions also significantly altered for beta diversity in all treatments (all p‐value = 0.001). An increased Cutibacterium with decreased Staphylococcus relative abundance was observed at months 1 and 3 in DC group, while an opposite trend was demonstrated in VAA and BP groups. These findings suggest a potential impact of DC, VAA and BP on the diversity and composition profiles of the skin microbiota in mild acne participants.
Subject
Dermatology,Molecular Biology,Biochemistry
Cited by
1 articles.
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